The promise of genomic medicine lies in the opportunity to improve health outcomes via a personalized approach to management, grounded in genetic and genomic variation unique to an individual. However, disparities and inequities mar this remarkable landscape of genomic innovation. Prior efforts to understand these inequities have focused on populations for which genetic testing is relatively protocolized or where test utility varies greatly by ancestry groups, where equitable outcomes are more clearly defined. We therefore consider the current landscape of rare (...) disease genomics, in which diagnostic approaches vary widely and utility remains to be fully understood, and suggest a path forward: how ecosocial theory may be used to guide novel equity‐focused initiatives that incorporate illness narratives to improve population health. We present examples of narrative medicine in rare disease and reimagine the role this discipline may play in genomic sequencing studies, toward incorporation of the unique illness narrative into clinical genetics and genomics practice. Approaches that broaden the definitions of disease and of outcomes of interest will force the field to grapple with its racist history and begin to advance health equity and promote justice so that genomic medicine may truly deliver on its promise. (shrink)

The development of transplantation technology increasingly places before society a multitude of diverse, complex ethical and legal problems. The subject is the more complex because of the various divergent interests involved. There are the interests of the donor of organs, who has a right to protection of his legal position, and those of the patient in need of an often lifesaving organ. There are also the interests of the donor’s relatives, after his death, and those of the transplantation surgeons. The (...) international dimension of transplantation technology makes the picture even more complicated. Though this article is devoted to the European situation, the problems are similar all over the world. (shrink)

It is demonstrated that neither the arguments leading to inconsistencies in the description of quantum-mechanical measurement nor those “explaining” the process of measurement by means of thermodynamical statistics are valid. Instead, it is argued that the probability interpretation is compatible with an objective interpretation of the wave function.

Dans ce volume considérable, on été réunies les contributions d'un Congrès international tenu à Louvain en 1998 pour marquer l'achèvement de la première édition de la Théologie Platonicienne de Proclus. Ces contributions, toutes rigoureusement centrées sur la Théol. Plat. concernent (1) les principes et les sources de la Théol. plat. (2) Les méthodes théologiques de Proclus (3) La postérité de la Théol. plat. dans le monde grec, païen comme chrétien, et dans le monde islamique. Des indices très détaillés permettent de (...) retrouver tous les passages cités et commentés dans ce volume. (shrink)

The program of a physical concept of information is outlined in the framework of quantum theory. A proposal is made for how to avoid the intuitive introduction of observables. The conventional and the Everett interpretations in principle may lead to different dynamical consequences. An ensemble description occurs without the introduction of an abstract concept of information.

Originally published in 1936, this book presents the ancient Greek text of the paraphrases and quotations of Zeno's philosophical arguments, together with a facing-page English translation and editorial commentary. Detailed notes are incorporated throughout and a bibliography is also included. This book will be of value to anyone with an interest in Zeno and ancient philosophy.

The relation between quantum measurement and thermodynamically irreversible processes is investigated. The reduction of the state vector is fundamentally asymmetric in time and shows an observer-relatedness which may explain the double interpretation of the state vector as a representation of physical states as well as ofinformation about physical states. The concept of relevance being used in all statistical theories of irreversible thermodynamics is demonstrated to be based on the same observer-relatedness. Quantum theories of irreversible processes implicitly use an objectivized process (...) of state vector reduction. The conditions for the reduction are discussed, and it is concluded that the final (subjective) observer system may be carried by a space point. (shrink)

This volume offers a collection of in-depth explorations of pragmatism as a framework for discussions in philosophy of science and metaphysics. Each chapter involves explicit reflection on what it means to be pragmatist, and how to use pragmatism as a guiding framework in addressing topics such as realism, unification, fundamentality, truth, laws, reduction, and more. -/- .

H. D. Lewis; I—Mind and Body—Some Observations on Mr. Strawson's Views: The Presidential Address, Proceedings of the Aristotelian Society, Volume 63, Issue 1, 1.

The interpretations of measurements in Bohm's and Everett's quantum theories are compared. Since both theories are based on the assumption of a universally valid Schrödinger equation, they face the common problem of how to explain that arrow of time, which in conventional quantum theory is represented by the collapse of the wave function. Its solution requires, in a statistical sense, a very improbable initial condition for thetotal wave function of the universe. The historical importance of Bohm's quantum theory is pointed (...) out. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:86 HISTORY OF PHILOSOPHY lamblichi Chalcidensis ex Coele-Syria de vita Pythagorica liber, lamblichos, Pythagoras. Legende--Lehre---Lebensgestaltung. Griechisch und Deutsch, herausgegeben, iibersetzt und eingeleitet von Michael yon Albrecht. (Ziirich & Stuttgart: Artemis, 1963. Pp. 280. = Die Bibliothek der Alten Welt, Reihe Antike und Christentum.) The present edition and translation again makes available one of the texts most valuable for the understanding of the world of late antiquity. The earlier editions, (...) especially that of L. Deubner (1937), are out of print. The fact that this document has been translated into German for the first time is also very helpful, since Iamblichos is sometimes difficult to understand. A brief but nevertheless informative introduction rightly emphasizes that Iamblichos intended to present an introduction and initiation into the Pythagorean way of life rather than a biography of Pythagoras based upon historically trustworthy materials. Although the biography of Pythagoras is certainly a part of the book, it serves only as the ideal example of the Pythagorean way of life, as Iaznblichos sees it. However, more than merely a work of Iamblichos, it ought to be recognized as a "fundamental document of the image of man in later antiquity" (p. 11). The text is based upon L. Deubner's edition, but occasionally it takes up older conjectures or returns to the tradition (for a more detailed discussion cf. W. Burkert, Gnomon 37, 1965, 24ff.). The index and the explanatory notes are also helpful, although the latter prove to be too brief and do not adequately call the reader's attention to the problems of sources, tradition, and composition. One can only agree with von Albrecht that we still need a modem commentary (p. I1). H. D. BETZ Claremont, CaliIornia Agrippa and the Crisis o] Renaissance Thought. By Charles G. Nauert, Jr. (Urbana: University of Illinois Press, 1965. Pp. vi W 374. $8.00.) One of the most influential and widely read thinkers of the early sixteenth century was the German Heinrich Cornelius Agrippa von Nettisheim (1486-1535). His many works were reprinted often, as well as being translated into several vernacular languages. The De incertitudine et vanitate omnium scientiarum et atrium of 1526, for example, went through at least 16 printings before 1700 and appeared in Italian (1547), English (1569), French (1582), and Dutch (1651) translations, which were themselves often reprinted. Although interest in Agrippa has waned somewhat since the seventeenth century, there is still a significant amount of scholarly debate regarding his importance and the meaning of his writings. Professor Nauert's monograph is the fruit of many years' study of Agrippa's life, thought, and milieu. In it he clearly places Agrippa in his historical context, accurately sketching his background and influence. After a brief introduction (pp. 1-7), the study is essentially divided into two parts: The first (pp. 8-115) traces Agrippa's life and intellectual development, the second (pp. 116-334) discusses in some detail a number of the key themes developed in his writings. There is also a substantial bibliography (pp. 335-,355) and a quite complete and accurate index (pp. 357-374). Although the mass of material which Nanert brings to our attention indicates the opposite, one sometimes gets the impression that the author tends to underestimate the importance of his subject. For example, he says, "Agrippa von Nettisheim is now a forgotten figure in the intellectual history of the West" (p. 322), but this does not seem to be the case. Although much work remains to be done, at least five books have been devoted to Agrippa in the past half century and, indeed, at least seven articles have appeared in the past ten years on one or another aspect of his life and thought. The very fact that Nanert can argue with so much vigor against the views of contemporary scholars like Lynn Thomdike and Paola Zambelli indicates that it is anything but a dead issue. As it is, Nauert's book clearly and accurately describes Agrippa's place in the intellectual ambiance of the sixteenth century. It gives the first detailed analysis of Agrippa's life and thought in English in recent BOOK REVIEWS 87 times and is the first full*scale attempt to exhaustively treat... (shrink)

The problem which I propose to consider is not whether the distinctions past, present, future, characterize the form of time in such a way that whatever may be true concerning the reality of one of these characteristics must be equally true of the others, but the more particular question of the kind of existence which belongs to the content of the past, or its constituents as events.

Autobiographical essay covering the first twenty five years of the author's life.

It is argued by means of analogy with certain irreversible processes that a symmetry-violating vacuum need not necessarily be explained by a special cosmic initial condition.

If I were asked to put forward an ethical principle which I considered to be especially certain, it would be that no one can be responsible, in the properly ethical sense, for the conduct of another. Responsibility belongs essentially to the individual. The implications of this principle are much more far-reaching than is evident at first, and reflection upon them may lead many to withdraw the assent which they might otherwise be very ready to accord to this view of responsibility. (...) But if the difficulties do appear to be insurmountable, and that, very certainly, does not seem to me to be the case, then the proper procedure will be, not to revert to the barbarous notion of collective or group responsibility, but to give up altogether the view that we are accountable in any distinctively moral sense. (shrink)